Interações medicamentosas
Captopril-hydrochlorothiazide + Sacubitril / valsartan
Gravidade: Contraindicada
Captopril-hydrochlorothiazide and Sacubitril / valsartan: contraindicated interaction.
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Resumo
Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
O que esta interação significa em palavras simples
Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Concurrent inhibition of neprilysin and ACE reduces bradykinin degradation, causing excess bradykinin-mediated angioedema.
O que fazer
Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicada
- Captopril-hydrochlorothiazide + Dofetilide Contraindicada
- Aceclofenac + Captopril-hydrochlorothiazide Grave
- Aldesleukin + Captopril-hydrochlorothiazide Grave
- Amifostine + Captopril-hydrochlorothiazide Grave
- Amiloride + Captopril-hydrochlorothiazide Grave
Perguntas frequentes
Can I take Captopril-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
How serious is the interaction between Captopril-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Captopril-hydrochlorothiazide page.
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