Interações medicamentosas
Carbenoxolone + Chlorthalidone
Gravidade: Grave
Carbenoxolone and Chlorthalidone: major interaction.
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Resumo
Carbenoxolone has mineralocorticoid-like activity and causes sodium retention and potassium loss. With chlorthalidone, the risk of marked hypokalemia and fluid retention is increased.
O que esta interação significa em palavras simples
Carbenoxolone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, enhancing mineralocorticoid effect on renal potassium excretion, which adds to diuretic potassium wasting.
O que fazer
Avoid the combination if possible; otherwise monitor serum potassium and blood pressure frequently and replace potassium as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlorthalidone
Perguntas frequentes
Can I take Carbenoxolone with Chlorthalidone?
MediHelp rates the interaction as major. Carbenoxolone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity and causes sodium retention and potassium loss. With chlorthalidone, the risk of marked hypokalemia and fluid retention is increased.
How serious is the interaction between Carbenoxolone and Chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor serum potassium and blood pressure frequently and replace potassium as needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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