Interações medicamentosas
Cholestyramine + Mycophenolic acid
Gravidade: Grave
Cholestyramine and Mycophenolic acid: major interaction.
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Resumo
Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
O que esta interação significa em palavras simples
Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Mycophenolic acid belongs to Miscellaneous.
Por que acontece
Bile acid sequestrant binds mycophenolate glucuronide and MPA in the gut, preventing reabsorption.
O que fazer
Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Mycophenolic acid
Outras interações de Cholestyramine
Perguntas frequentes
Can I take Cholestyramine with Mycophenolic acid?
MediHelp rates the interaction as major. Cholestyramine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds mycophenolic acid and interrupts its enterohepatic recirculation, substantially lowering exposure. This may cause loss of immunosuppressive effect and graft rejection.
How serious is the interaction between Cholestyramine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative lipid-lowering agent. If unavoidable, monitor for rejection and consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Ganciclovir. The full list is on the Mycophenolic acid page.
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