Interações medicamentosas
Clozapine + Irinotecan
Gravidade: Contraindicada
Clozapine and Irinotecan: contraindicated interaction.
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Resumo
Clozapine can cause severe neutropenia or agranulocytosis, and irinotecan commonly causes dose-limiting neutropenia. Combined use makes profound myelosuppression and serious infection more likely.
O que esta interação significa em palavras simples
Clozapine and Irinotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clozapine belongs to Central Nervous System; Irinotecan belongs to Oncology.
Por que acontece
Additive bone marrow suppression
O que fazer
Avoid combined use; if irinotecan is essential, stop clozapine or use an alternative and monitor blood counts closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
- Adrenaline-articaine + Clozapine Grave
Outras interações de Irinotecan
- Irinotecan + Sacituzumab govitecan Contraindicada
- Adenovirus types 4 and 7 live + Irinotecan Grave
- Apalutamide + Irinotecan Grave
- Atazanavir + Irinotecan Grave
- Carbamazepine + Irinotecan Grave
- Clarithromycin + Irinotecan Grave
Perguntas frequentes
Can I take Clozapine with Irinotecan?
MediHelp rates the interaction as contraindicated. Clozapine and Irinotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clozapine can cause severe neutropenia or agranulocytosis, and irinotecan commonly causes dose-limiting neutropenia. Combined use makes profound myelosuppression and serious infection more likely.
How serious is the interaction between Clozapine and Irinotecan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use; if irinotecan is essential, stop clozapine or use an alternative and monitor blood counts closely.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Pimozide, Thioridazine. The full list is on the Clozapine page.
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