Interações medicamentosas
Darunavir + Fluticasone-salmeterol
Gravidade: Contraindicada
Darunavir and Fluticasone-salmeterol: contraindicated interaction.
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Resumo
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
O que esta interação significa em palavras simples
Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Fluticasone-salmeterol belongs to Respiratory.
Por que acontece
Strong CYP3A4 inhibition by the boosted protease inhibitor reduces salmeterol and fluticasone clearance.
O que fazer
Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fluticasone-salmeterol
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicada
- Fluticasone-salmeterol + Fosamprenavir Contraindicada
- Fluticasone-salmeterol + Indinavir Contraindicada
- Fluticasone-salmeterol + Lopinavir Contraindicada
- Fluticasone-salmeterol + Nelfinavir Contraindicada
- Fluticasone-salmeterol + Ritonavir Contraindicada
Outras interações de Darunavir
- Alfuzosin + Darunavir Contraindicada
- Avanafil + Darunavir Contraindicada
- Darunavir + Dronedarone Contraindicada
- Darunavir + Eletriptan Contraindicada
- Darunavir + Ergotamine Contraindicada
- Darunavir + Flibanserin Contraindicada
Perguntas frequentes
Can I take Darunavir with Fluticasone-salmeterol?
MediHelp rates the interaction as contraindicated. Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
How serious is the interaction between Darunavir and Fluticasone-salmeterol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir, Indinavir. The full list is on the Fluticasone-salmeterol page.
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