Interações medicamentosas
Dengue vaccine + Fluorouracil
Gravidade: Grave
Dengue vaccine and Fluorouracil: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Dengue vaccine is live attenuated. Immunosuppression from fluorouracil may reduce the immune response and could permit vaccine virus disease in a significantly immunocompromised patient.
O que esta interação significa em palavras simples
Dengue vaccine and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cytotoxic antimetabolite-induced immunosuppression reduces vaccine response and impairs control of the live vaccine virus.
O que fazer
Avoid live dengue vaccine during fluorouracil chemotherapy; vaccinate only after immune recovery per labeling and specialist advice.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fluorouracil
Perguntas frequentes
Can I take Dengue vaccine with Fluorouracil?
MediHelp rates the interaction as major. Dengue vaccine and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is live attenuated. Immunosuppression from fluorouracil may reduce the immune response and could permit vaccine virus disease in a significantly immunocompromised patient.
How serious is the interaction between Dengue vaccine and Fluorouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during fluorouracil chemotherapy; vaccinate only after immune recovery per labeling and specialist advice.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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