Interações medicamentosas
Diflunisal + Ketorolac intranasal
Gravidade: Contraindicada
Diflunisal and Ketorolac intranasal: contraindicated interaction.
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Resumo
Ketorolac labeling contraindicates concurrent NSAIDs, including aspirin-type salicylates such as diflunisal. The combination adds gastrointestinal bleeding, ulcer and renal injury risk without added analgesic benefit.
O que esta interação significa em palavras simples
Diflunisal and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
O que fazer
Do not use together. Use a single NSAID at a time and allow washout before switching.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Diflunisal
- Diflunisal + Ketorolac Contraindicada
- Acemetacin + Diflunisal Grave
- Acetazolamide + Diflunisal Grave
- Alteplase + Diflunisal Grave
- Amiloride + Diflunisal Grave
- Amlodipine-hydrochlorothiazide-valsartan + Diflunisal Grave
Perguntas frequentes
Can I take Diflunisal with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Diflunisal and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac labeling contraindicates concurrent NSAIDs, including aspirin-type salicylates such as diflunisal. The combination adds gastrointestinal bleeding, ulcer and renal injury risk without added analgesic benefit.
How serious is the interaction between Diflunisal and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use a single NSAID at a time and allow washout before switching.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Acemetacin, Acetazolamide. The full list is on the Diflunisal page.
Monografias completas, posologia e verificador de interações no app MediHelp
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