Interações medicamentosas
Dihydroergotamine intranasal + Ketoconazole
Gravidade: Contraindicada
Dihydroergotamine intranasal and Ketoconazole: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Ketoconazole raises systemic exposure to dihydroergotamine even when it is given intranasally. This increases the risk of serious vasospasm and ischemia, and the combination is contraindicated in labeling.
O que esta interação significa em palavras simples
Dihydroergotamine intranasal and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Strong CYP3A4 inhibition by ketoconazole reduces the metabolic clearance of dihydroergotamine.
O que fazer
Avoid the combination. Choose a non-ergot acute migraine therapy while ketoconazole is being used.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dihydroergotamine intranasal e Ketoconazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Ketoconazole
- Alfuzosin + Ketoconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Avanafil + Ketoconazole Contraindicada
- Conivaptan + Ketoconazole Contraindicada
- Dihydroergotamine + Ketoconazole Contraindicada
- Disopyramide + Ketoconazole Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine intranasal with Ketoconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole raises systemic exposure to dihydroergotamine even when it is given intranasally. This increases the risk of serious vasospasm and ischemia, and the combination is contraindicated in labeling.
How serious is the interaction between Dihydroergotamine intranasal and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose a non-ergot acute migraine therapy while ketoconazole is being used.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
