Interações medicamentosas
Dimethyl fumarate + Diroximel fumarate
Gravidade: Contraindicada
Dimethyl fumarate and Diroximel fumarate: contraindicated interaction.
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Resumo
Both drugs are converted to the same active metabolite, monomethyl fumarate, so combining them duplicates therapy. This raises the risk of flushing, gastrointestinal effects, lymphopenia and other dose-related adverse effects.
O que esta interação significa em palavras simples
Dimethyl fumarate and Diroximel fumarate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dimethyl fumarate belongs to Central Nervous System; Diroximel fumarate belongs to Central Nervous System.
Por que acontece
Both prodrugs yield monomethyl fumarate, producing additive exposure.
O que fazer
Do not use together. Diroximel fumarate may be started the day after dimethyl fumarate is stopped.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Perguntas frequentes
Can I take Dimethyl fumarate with Diroximel fumarate?
MediHelp rates the interaction as contraindicated. Dimethyl fumarate and Diroximel fumarate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are converted to the same active metabolite, monomethyl fumarate, so combining them duplicates therapy. This raises the risk of flushing, gastrointestinal effects, lymphopenia and other dose-related adverse effects.
How serious is the interaction between Dimethyl fumarate and Diroximel fumarate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Diroximel fumarate may be started the day after dimethyl fumarate is stopped.
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