Interações medicamentosas
Dipyridamole + Regadenoson
Gravidade: Grave
Dipyridamole and Regadenoson: major interaction.
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Resumo
Dipyridamole inhibits cellular adenosine uptake and deamination, which can potentiate adenosine receptor-mediated effects and alter the response to the A2A agonist regadenoson during myocardial perfusion imaging. The result may be unpredictable vasodilation, hypotension or altered test performance.
O que esta interação significa em palavras simples
Dipyridamole and Regadenoson can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dipyridamole belongs to Cardiovascular; Regadenoson belongs to Cardiovascular.
Por que acontece
Dipyridamole raises adenosine levels and alters adenosine receptor signaling, so the pharmacodynamic response to regadenoson is unpredictable.
O que fazer
Withhold dipyridamole for at least 2 days before regadenoson stress testing, as recommended in labeling. Monitor blood pressure and ECG during the procedure if exposure cannot be avoided.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dipyridamole
- Dipyridamole + Riociguat Contraindicada
- Adenosine + Dipyridamole Grave
- Betrixaban + Dipyridamole Grave
- Dabigatran + Dipyridamole Grave
- Dipyridamole + Venetoclax Grave
- Dipyridamole + Vorapaxar Grave
Outras interações de Regadenoson
- Regadenoson + Theophylline Grave
- Caffeine + Regadenoson Moderada
Perguntas frequentes
Can I take Dipyridamole with Regadenoson?
MediHelp rates the interaction as major. Dipyridamole and Regadenoson can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipyridamole inhibits cellular adenosine uptake and deamination, which can potentiate adenosine receptor-mediated effects and alter the response to the A2A agonist regadenoson during myocardial perfusion imaging. The result may be unpredictable vasodilation, hypotension or altered test performance.
How serious is the interaction between Dipyridamole and Regadenoson?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold dipyridamole for at least 2 days before regadenoson stress testing, as recommended in labeling. Monitor blood pressure and ECG during the procedure if exposure cannot be avoided.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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