Interações medicamentosas
Droperidol + Tolterodine
Gravidade: Grave
Droperidol and Tolterodine: major interaction.
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Resumo
Droperidol prolongs the QT interval and tolterodine may also affect QT, so the combination may increase the risk of torsades de pointes, particularly with other risk factors. Additive anticholinergic effects may also occur.
O que esta interação significa em palavras simples
Droperidol and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive QT interval prolongation and additive anticholinergic effects.
O que fazer
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before droperidol. Avoid the combination in patients with QT risk factors and monitor ECG if it is needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tolterodine
Perguntas frequentes
Can I take Droperidol with Tolterodine?
MediHelp rates the interaction as major. Droperidol and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol prolongs the QT interval and tolterodine may also affect QT, so the combination may increase the risk of torsades de pointes, particularly with other risk factors. Additive anticholinergic effects may also occur.
How serious is the interaction between Droperidol and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before droperidol. Avoid the combination in patients with QT risk factors and monitor ECG if it is needed.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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