Interações medicamentosas
Drospirenone + Ivosidenib
Gravidade: Grave
Drospirenone and Ivosidenib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.
O que esta interação significa em palavras simples
Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Drospirenone belongs to Endocrine; Ivosidenib belongs to Oncology.
Por que acontece
Ivosidenib induces CYP3A4, increasing the metabolism of drospirenone and lowering its concentrations.
O que fazer
Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Drospirenone
Outras interações de Ivosidenib
- Alfuzosin + Ivosidenib Grave
- Amiodarone + Ivosidenib Grave
- Amisulpride + Ivosidenib Grave
- Amitriptyline + Ivosidenib Grave
- Amobarbital + Ivosidenib Grave
- Anagrelide + Ivosidenib Grave
Perguntas frequentes
Can I take Drospirenone with Ivosidenib?
MediHelp rates the interaction as major. Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.
How serious is the interaction between Drospirenone and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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