Interações medicamentosas
Exemestane + Mitotane
Gravidade: Grave
Exemestane and Mitotane: major interaction.
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Resumo
Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
O que esta interação significa em palavras simples
Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Exemestane belongs to Oncology; Mitotane belongs to Oncology.
Por que acontece
Mitotane induces CYP3A4, accelerating the metabolism of exemestane.
O que fazer
Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Exemestane
Outras interações de Mitotane
- Doravirine + Mitotane Contraindicada
- Fostemsavir + Mitotane Contraindicada
- Lorlatinib + Mitotane Contraindicada
- Abiraterone + Mitotane Grave
- Apixaban + Mitotane Grave
- Aprepitant + Mitotane Grave
Perguntas frequentes
Can I take Exemestane with Mitotane?
MediHelp rates the interaction as major. Exemestane and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer that persists for weeks after discontinuation and can substantially lower exemestane concentrations. Reduced exposure may compromise the antiestrogenic effect of treatment.
How serious is the interaction between Exemestane and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase exemestane to 50 mg daily after a meal when a strong CYP3A4 inducer is co-administered, and monitor treatment response. Consider that the induction continues after mitotane is stopped.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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