Interações medicamentosas
Fluorouracil + Leucovorin
Gravidade: Grave
Fluorouracil and Leucovorin: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
O que esta interação significa em palavras simples
Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluorouracil belongs to Oncology; Leucovorin belongs to Miscellaneous.
Por que acontece
Leucovorin supplies reduced folate that stabilizes the binding of fluorodeoxyuridylate to thymidylate synthase, enhancing both efficacy and toxicity.
O que fazer
Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Fluorouracil
Outras interações de Leucovorin
- Capecitabine + Leucovorin Grave
- Glucarpidase + Leucovorin Grave
- Leucovorin + Phenobarbitone Moderada
- Leucovorin + Phenytoin Moderada
Perguntas frequentes
Can I take Fluorouracil with Leucovorin?
MediHelp rates the interaction as major. Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
How serious is the interaction between Fluorouracil and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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