Interações medicamentosas
Fosinopril + Protein a column
Gravidade: Contraindicada
Fosinopril and Protein a column: contraindicated interaction.
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Resumo
Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
O que esta interação significa em palavras simples
Fosinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
ACE inhibition blocks kininase II degradation of bradykinin, which is increased by column-mediated contact activation, causing anaphylactoid reactions.
O que fazer
Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fosinopril
- Aliskiren + Fosinopril Contraindicada
- Fosinopril + Sacubitril / valsartan Contraindicada
- Fosinopril + Sacubitril-valsartan Contraindicada
- Amifostine + Fosinopril Grave
- Amiloride + Fosinopril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Fosinopril Grave
Perguntas frequentes
Can I take Fosinopril with Protein a column?
MediHelp rates the interaction as contraindicated. Fosinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
How serious is the interaction between Fosinopril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Fosinopril page.
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