Interações medicamentosas
Ibutilide + Mefloquine
Gravidade: Contraindicada
Ibutilide and Mefloquine: contraindicated interaction.
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Resumo
Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Mefloquine can add to repolarization delay, so the combination increases the risk of life-threatening arrhythmia.
O que esta interação significa em palavras simples
Ibutilide and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Por que acontece
Additive QT prolongation, with ibutilide as a potent IKr blocker.
O que fazer
Do not combine. Select an alternative antimalarial, and if mefloquine was recently taken, consider its long half-life before giving ibutilide.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Mefloquine
- Arsenic trioxide + Mefloquine Contraindicada
- Dronedarone + Mefloquine Contraindicada
- Levoketoconazole + Mefloquine Contraindicada
- Mefloquine + Nilotinib Contraindicada
- Mefloquine + Pimozide Contraindicada
- Mefloquine + Quinidine Contraindicada
Outras interações de Ibutilide
- Amiodarone + Ibutilide Contraindicada
- Amisulpride + Ibutilide Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Clarithromycin + Ibutilide Contraindicada
- Desipramine + Ibutilide Contraindicada
- Dolasetron + Ibutilide Contraindicada
Perguntas frequentes
Can I take Ibutilide with Mefloquine?
MediHelp rates the interaction as contraindicated. Ibutilide and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Mefloquine can add to repolarization delay, so the combination increases the risk of life-threatening arrhythmia.
How serious is the interaction between Ibutilide and Mefloquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Select an alternative antimalarial, and if mefloquine was recently taken, consider its long half-life before giving ibutilide.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Levoketoconazole. The full list is on the Mefloquine page.
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