Interações medicamentosas
Lapatinib + Saquinavir
Gravidade: Contraindicada
Lapatinib and Saquinavir: contraindicated interaction.
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Resumo
Saquinavir, usually boosted with ritonavir, is a strong CYP3A4 inhibitor that can greatly raise lapatinib exposure. Both drugs prolong the QT interval, so the risk of torsades de pointes and lapatinib toxicity increases.
O que esta interação significa em palavras simples
Lapatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Saquinavir inhibits CYP3A4 metabolism of lapatinib, with additive QT prolongation.
O que fazer
Avoid the combination and choose an alternative antiretroviral or kinase inhibitor. If it cannot be avoided, reduce lapatinib dose substantially and monitor ECG closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Lapatinib
- Dofetilide + Lapatinib Contraindicada
- Ibutilide + Lapatinib Contraindicada
- Lapatinib + Pimozide Contraindicada
- Lapatinib + Thioridazine Contraindicada
- Adagrasib + Lapatinib Grave
- Amiodarone + Lapatinib Grave
Perguntas frequentes
Can I take Lapatinib with Saquinavir?
MediHelp rates the interaction as contraindicated. Lapatinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir, usually boosted with ritonavir, is a strong CYP3A4 inhibitor that can greatly raise lapatinib exposure. Both drugs prolong the QT interval, so the risk of torsades de pointes and lapatinib toxicity increases.
How serious is the interaction between Lapatinib and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiretroviral or kinase inhibitor. If it cannot be avoided, reduce lapatinib dose substantially and monitor ECG closely.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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