Interações medicamentosas
Meropenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravidade: Moderada
Meropenem and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. A broad-spectrum carbapenem such as meropenem can suppress colonic flora and may reduce the bowel-cleansing effect before colonoscopy.
O que esta interação significa em palavras simples
Meropenem and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Antibiotic-induced reduction of colonic bacteria impairs conversion of sodium picosulfate to its active metabolite.
O que fazer
Watch for inadequate bowel preparation in patients on the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting the antibiotic during the preparation window.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Meropenem
- Meropenem + Valproic acid Contraindicada
- Meropenem + Typhoid vaccine live Grave
- Amifampridine + Meropenem Moderada
- Cholera vaccine + Meropenem Moderada
- Meropenem + Microbiota Moderada
- Meropenem + Probenecid Moderada
Perguntas frequentes
Can I take Meropenem with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Meropenem and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. A broad-spectrum carbapenem such as meropenem can suppress colonic flora and may reduce the bowel-cleansing effect before colonoscopy.
How serious is the interaction between Meropenem and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for inadequate bowel preparation in patients on the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting the antibiotic during the preparation window.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Typhoid vaccine live, Amifampridine. The full list is on the Meropenem page.
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