Interações medicamentosas
Moexipril + Protein a column
Gravidade: Contraindicada
Moexipril and Protein a column: contraindicated interaction.
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Resumo
Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
O que esta interação significa em palavras simples
Moexipril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
ACE inhibition blocks kininase II degradation of bradykinin, which is increased by column-mediated contact activation, causing anaphylactoid reactions.
O que fazer
Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Moexipril
- Aliskiren + Moexipril Contraindicada
- Moexipril + Sacubitril / valsartan Contraindicada
- Moexipril + Sacubitril-valsartan Contraindicada
- Amifostine + Moexipril Grave
- Amiloride + Moexipril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Moexipril Grave
Perguntas frequentes
Can I take Moexipril with Protein a column?
MediHelp rates the interaction as contraindicated. Moexipril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors who undergo apheresis with a protein A immunoadsorption column can develop anaphylactoid reactions such as flushing, hypotension and dyspnea. Bradykinin accumulates because ACE inhibition prevents its breakdown, and the column activates the kinin system.
How serious is the interaction between Moexipril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; stop the ACE inhibitor well before the procedure (about 72 hours per labeling) or use an alternative antihypertensive class. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Moexipril page.
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