Interações medicamentosas
Papain + Silver sulfadiazine
Gravidade: Moderada
Papain and Silver sulfadiazine: moderate interaction.
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Resumo
Silver from silver sulfadiazine can inactivate papain, a proteolytic debriding enzyme, when both are used on the same wound. Debridement may be less effective.
O que esta interação significa em palavras simples
Papain and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Silver heavy metal ions inactivate the enzyme protein.
O que fazer
Do not use together on the same wound site. Thoroughly clean off silver sulfadiazine before applying papain.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Silver sulfadiazine
Perguntas frequentes
Can I take Papain with Silver sulfadiazine?
MediHelp rates the interaction as moderate. Papain and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silver from silver sulfadiazine can inactivate papain, a proteolytic debriding enzyme, when both are used on the same wound. Debridement may be less effective.
How serious is the interaction between Papain and Silver sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together on the same wound site. Thoroughly clean off silver sulfadiazine before applying papain.
What other medicines interact with Silver sulfadiazine?
MediHelp also lists interactions of Silver sulfadiazine with, for example, Allogeneic cultured keratinocytes and fibroblasts, Collagenase, Trypsin. The full list is on the Silver sulfadiazine page.
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