Interações medicamentosas
Pexidartinib + Sulphasalazine
Gravidade: Grave
Pexidartinib and Sulphasalazine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
O que esta interação significa em palavras simples
Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Por que acontece
Additive hepatotoxicity from two agents that can each cause liver injury.
O que fazer
Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Sulphasalazine
- Deferiprone + Sulphasalazine Grave
- Sepiapterin + Sulphasalazine Grave
- Acalabrutinib + Sulphasalazine Moderada
- Aceclofenac + Sulphasalazine Moderada
- Acetazolamide + Sulphasalazine Moderada
- Asciminib + Sulphasalazine Moderada
Outras interações de Pexidartinib
Perguntas frequentes
Can I take Pexidartinib with Sulphasalazine?
MediHelp rates the interaction as major. Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
How serious is the interaction between Pexidartinib and Sulphasalazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Sepiapterin, Acalabrutinib. The full list is on the Sulphasalazine page.
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