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Interações medicamentosas

Pimozide + Primaquine

Gravidade: Contraindicada

Pimozide and Primaquine: contraindicated interaction.

Última atualização Fontes: US FDA label

Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Both drugs can prolong the QT interval, and pimozide carries a notable risk of torsades de pointes. Giving them together raises the chance of a life-threatening ventricular arrhythmia.

O que esta interação significa em palavras simples

Pimozide and Primaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Pimozide belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.

Nível de evidência: Moderate

Por que acontece

Additive pharmacodynamic QT prolongation through cardiac repolarization (potassium channel) blockade.

O que fazer

Avoid the combination and choose an alternative antimalarial for radical cure if pimozide is required. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before treatment.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Referências

Perguntas frequentes

Can I take Pimozide with Primaquine?

MediHelp rates the interaction as contraindicated. Pimozide and Primaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and pimozide carries a notable risk of torsades de pointes. Giving them together raises the chance of a life-threatening ventricular arrhythmia.

How serious is the interaction between Pimozide and Primaquine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antimalarial for radical cure if pimozide is required. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before treatment.

What other medicines interact with Primaquine?

MediHelp also lists interactions of Primaquine with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Primaquine page.

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