Interações medicamentosas
Pimozide + Quinine
Gravidade: Contraindicada
Pimozide and Quinine: contraindicated interaction.
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Resumo
Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Por que acontece
Additive QT prolongation with quinine inhibition of CYP2D6-mediated pimozide metabolism.
O que fazer
Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Quinine
- Arsenic trioxide + Quinine Contraindicada
- Dofetilide + Quinine Contraindicada
- Dronedarone + Quinine Contraindicada
- Ibutilide + Quinine Contraindicada
- Mefloquine + Quinine Contraindicada
- Nilotinib + Quinine Contraindicada
Outras interações de Pimozide
- Adagrasib + Pimozide Contraindicada
- Amiodarone + Pimozide Contraindicada
- Amisulpride + Pimozide Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amoxapine + Pimozide Contraindicada
- Anagrelide + Pimozide Contraindicada
Perguntas frequentes
Can I take Pimozide with Quinine?
MediHelp rates the interaction as contraindicated. Pimozide and Quinine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and quinine also inhibits CYP2D6, potentially raising pimozide levels. The combination markedly raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Pimozide and Quinine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antimalarial or antipsychotic. If quinine is essential, stop pimozide and monitor the ECG.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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