Лекарственные взаимодействия
Adenovirus types 4 and 7 live + Certolizumab pegol
Тяжесть: Противопоказано
Adenovirus types 4 and 7 live and Certolizumab pegol: contraindicated interaction.
Последнее обновление
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Кратко
The oral adenovirus type 4 and 7 vaccine contains live virus. Under TNF blockade with certolizumab, replication may be poorly controlled, risking vaccine-related infection and a reduced immune response.
Что означает это взаимодействие простыми словами
Adenovirus types 4 and 7 live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
TNF inhibition impairs immune control of live attenuated virus, raising infection risk and reducing vaccine response.
Что делать
Avoid this live vaccine during certolizumab therapy. Vaccinate before starting treatment if indicated, allowing at least 4 weeks.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Certolizumab pegol
- Bcg intravesical live + Certolizumab pegol Противопоказано
- Bcg vaccine live + Certolizumab pegol Противопоказано
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Противопоказано
- Certolizumab pegol + Measles mumps and rubella vaccine Противопоказано
- Certolizumab pegol + Measles mumps and rubella vaccine live Противопоказано
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Противопоказано
Частые вопросы
Can I take Adenovirus types 4 and 7 live with Certolizumab pegol?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The oral adenovirus type 4 and 7 vaccine contains live virus. Under TNF blockade with certolizumab, replication may be poorly controlled, risking vaccine-related infection and a reduced immune response.
How serious is the interaction between Adenovirus types 4 and 7 live and Certolizumab pegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid this live vaccine during certolizumab therapy. Vaccinate before starting treatment if indicated, allowing at least 4 weeks.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Bcg intravesical live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.
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