Лекарственные взаимодействия
Bcg intravesical live + Certolizumab pegol
Тяжесть: Противопоказано
Bcg intravesical live and Certolizumab pegol: contraindicated interaction.
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Кратко
Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
Что означает это взаимодействие простыми словами
Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
TNF is essential for granuloma formation and mycobacterial containment, so its inhibition allows BCG dissemination.
Что делать
Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Противопоказано
- Bcg vaccine live + Certolizumab pegol Противопоказано
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Противопоказано
- Certolizumab pegol + Measles mumps and rubella vaccine Противопоказано
- Certolizumab pegol + Measles mumps and rubella vaccine live Противопоказано
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Противопоказано
Частые вопросы
Can I take Bcg intravesical live with Certolizumab pegol?
MediHelp rates the interaction as contraindicated. Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
How serious is the interaction between Bcg intravesical live and Certolizumab pegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.
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