Лекарственные взаимодействия
Ascorbic acid + Deferoxamine
Тяжесть: Тяжёлое
Ascorbic acid and Deferoxamine: major interaction.
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Кратко
Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
Что означает это взаимодействие простыми словами
Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Ascorbic acid increases the pool of chelatable iron, and the redox-active iron released may cause cardiac toxicity.
Что делать
Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Deferoxamine
- Betibeglogene autotemcel + Deferoxamine Тяжёлое
- Deferoxamine + Exagamglogene autotemcel Тяжёлое
- Deferoxamine + Lovotibeglogene autotemcel Тяжёлое
- Deferoxamine + Vitamin c Тяжёлое
- Carbonyl iron + Deferoxamine Умеренное
- Deferoxamine + Ferrous fumarate Умеренное
Частые вопросы
Can I take Ascorbic acid with Deferoxamine?
MediHelp rates the interaction as major. Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
How serious is the interaction between Ascorbic acid and Deferoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
What other medicines interact with Deferoxamine?
MediHelp also lists interactions of Deferoxamine with, for example, Betibeglogene autotemcel, Exagamglogene autotemcel, Lovotibeglogene autotemcel. The full list is on the Deferoxamine page.
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