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Лекарственные взаимодействия

Deferoxamine + Vitamin c

Тяжесть: Тяжёлое

Deferoxamine and Vitamin c: major interaction.

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Кратко

Vitamin C increases the amount of iron available for chelation by deferoxamine and can raise urinary iron excretion. In iron-overloaded patients, especially those with cardiac involvement, high-dose vitamin C has been linked to cardiac dysfunction, which can be serious.

Что означает это взаимодействие простыми словами

Deferoxamine and Vitamin c can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Deferoxamine belongs to Miscellaneous; Vitamin c belongs to Gastrointestinal Tract.

Уровень доказательности: Moderate

Почему это происходит

Ascorbic acid mobilizes tissue iron into a labile pool, which may increase iron-mediated myocardial toxicity while enhancing deferoxamine chelation.

Что делать

Avoid vitamin C in patients with cardiac dysfunction receiving deferoxamine. If it is used, start it only after a month of regular chelation, keep doses low, and monitor cardiac function.

О чём спросить фармацевта

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Частые вопросы

Can I take Deferoxamine with Vitamin c?

MediHelp rates the interaction as major. Deferoxamine and Vitamin c can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C increases the amount of iron available for chelation by deferoxamine and can raise urinary iron excretion. In iron-overloaded patients, especially those with cardiac involvement, high-dose vitamin C has been linked to cardiac dysfunction, which can be serious.

How serious is the interaction between Deferoxamine and Vitamin c?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin C in patients with cardiac dysfunction receiving deferoxamine. If it is used, start it only after a month of regular chelation, keep doses low, and monitor cardiac function.

What other medicines interact with Vitamin c?

MediHelp also lists interactions of Vitamin c with, for example, Aluminum hydroxide, Dextroamphetamine transdermal, Aspirin / citric acid / sodium bicarbonate. The full list is on the Vitamin c page.

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