Лекарственные взаимодействия
Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Тяжесть: Умеренное
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Последнее обновление
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Кратко
Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
Что означает это взаимодействие простыми словами
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Почему это происходит
Antibiotic-induced reduction of colonic bacteria impairs conversion of sodium picosulfate to its active metabolite.
Что делать
Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
О чём спросить фармацевта
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Другие взаимодействия Aztreonam
- Aztreonam + Cefoxitin Умеренное
- Aztreonam + Cholera vaccine Умеренное
- Aztreonam + Microbiota Умеренное
- Aztreonam + Typhoid vaccine live Умеренное
- Amikacin + Aztreonam Незначительное
- Amoxicillin-clavulanic acid + Aztreonam Незначительное
Частые вопросы
Can I take Aztreonam with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
How serious is the interaction between Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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