Drug interactions
Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
What this interaction means in plain words
Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic-induced reduction of colonic bacteria impairs conversion of sodium picosulfate to its active metabolite.
What to do
Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
- Amoxicillin-clavulanic acid + Aztreonam Minor
Frequently asked questions
Can I take Aztreonam with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to convert it into its active laxative form. Antibacterial agents that reduce colonic flora could weaken the bowel-cleansing effect before colonoscopy. Aztreonam has activity against gram-negative aerobes, and the label for the preparation warns about antibiotic use.
How serious is the interaction between Aztreonam and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be alert to inadequate bowel preparation in patients receiving the antibiotic and consider extra preparation or rescheduling if cleansing is poor. Where clinically possible, avoid starting the antibiotic course during the preparation window.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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