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Лекарственные взаимодействия

Belimumab + Measles mumps and rubella vaccine

Тяжесть: Тяжёлое

Belimumab and Measles mumps and rubella vaccine: major interaction.

Последнее обновление

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Кратко

Belimumab is a B-cell survival inhibitor that dampens immune function, so live vaccine viruses may replicate more and the vaccine response may be reduced. Labeling advises against live vaccines with belimumab.

Что означает это взаимодействие простыми словами

Belimumab and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Belimumab belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.

Уровень доказательности: Moderate

Почему это происходит

Inhibition of BLyS reduces B-cell activity, which may blunt vaccine response and impair control of live attenuated viruses.

Что делать

Do not give live vaccines within the 30 days before or during belimumab therapy. Update vaccinations beforehand.

О чём спросить фармацевта

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

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Частые вопросы

Can I take Belimumab with Measles mumps and rubella vaccine?

MediHelp rates the interaction as major. Belimumab and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belimumab is a B-cell survival inhibitor that dampens immune function, so live vaccine viruses may replicate more and the vaccine response may be reduced. Labeling advises against live vaccines with belimumab.

How serious is the interaction between Belimumab and Measles mumps and rubella vaccine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines within the 30 days before or during belimumab therapy. Update vaccinations beforehand.

What other medicines interact with Measles mumps and rubella vaccine?

MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.

Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp

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