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Лекарственные взаимодействия

Cefoxitin + Gentamicin

Тяжесть: Умеренное

Cefoxitin and Gentamicin: moderate interaction.

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Кратко

Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.

Что означает это взаимодействие простыми словами

Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefoxitin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.

Уровень доказательности: Low

Почему это происходит

Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.

Что делать

Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.

О чём спросить фармацевта

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Частые вопросы

Can I take Cefoxitin with Gentamicin?

MediHelp rates the interaction as moderate. Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.

How serious is the interaction between Cefoxitin and Gentamicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.

What other medicines interact with Cefoxitin?

MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.

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