Лекарственные взаимодействия
Clarithromycin + Colchicine
Тяжесть: Противопоказано
Clarithromycin and Colchicine: contraindicated interaction.
Последнее обновление Источники: US FDA label
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Кратко
Clarithromycin markedly increases colchicine exposure, and fatal colchicine toxicity has been reported with this combination. Presentations include severe gastrointestinal symptoms, myopathy, bone marrow suppression, multiorgan failure and death. Patients with renal or hepatic impairment and older adults are at greatest risk, but toxicity can occur even at standard colchicine doses.
Что означает это взаимодействие простыми словами
Clarithromycin and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Colchicine belongs to Genitourinary.
Почему это происходит
Clarithromycin inhibits both CYP3A4 and P-glycoprotein, reducing colchicine metabolism and efflux and raising systemic levels with a narrow therapeutic index.
Что делать
Avoid the combination, and choose a non-interacting antibiotic such as azithromycin or doxycycline where clinically appropriate. If a macrolide course is essential, withhold colchicine for the duration of treatment, and in patients with renal or hepatic impairment the combination should not be used at all.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Источники
Другие взаимодействия Colchicine
- Cobicistat + Colchicine Противопоказано
- Colchicine + Cyclosporine Противопоказано
- Colchicine + Ensitrelvir Противопоказано
- Colchicine + Levoketoconazole Противопоказано
- Colchicine + Nirmatrelvir Противопоказано
- Colchicine + Nirmatrelvir / ritonavir Противопоказано
Другие взаимодействия Clarithromycin
- Astemizole + Clarithromycin Противопоказано
- Avanafil + Clarithromycin Противопоказано
- Cisapride + Clarithromycin Противопоказано
- Clarithromycin + Conivaptan Противопоказано
- Clarithromycin + Dihydroergotamine Противопоказано
- Clarithromycin + Dihydroergotamine intranasal Противопоказано
Частые вопросы
Can I take Clarithromycin with Colchicine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly increases colchicine exposure, and fatal colchicine toxicity has been reported with this combination. Presentations include severe gastrointestinal symptoms, myopathy, bone marrow suppression, multiorgan failure and death. Patients with renal or hepatic impairment and older adults are at greatest risk, but toxicity can occur even at standard colchicine doses.
How serious is the interaction between Clarithromycin and Colchicine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and choose a non-interacting antibiotic such as azithromycin or doxycycline where clinically appropriate. If a macrolide course is essential, withhold colchicine for the duration of treatment, and in patients with renal or hepatic impairment the combination should not be used at all.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Cobicistat, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.
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