Drug interactions
clarithromycin + colchicine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Life-threatening toxicity; often contraindicated.
Mechanism of action
CYP3A4/P-gp inhibition → ↑ colchicine.
Clinical management
Avoid; if unavoidable, drastic dose reduction with monitoring.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with colchicine?
The interaction is rated: Contraindicated. Life-threatening toxicity; often contraindicated.
How serious is the interaction between clarithromycin and colchicine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between clarithromycin and colchicine managed?
Avoid; if unavoidable, drastic dose reduction with monitoring.
Why do clarithromycin and colchicine interact?
CYP3A4/P-gp inhibition → ↑ colchicine.
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