Лекарственные взаимодействия
Cyclobenzaprine + Isocarboxazid
Тяжесть: Противопоказано
Cyclobenzaprine and Isocarboxazid: contraindicated interaction.
Последнее обновление
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Кратко
Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Что означает это взаимодействие простыми словами
Cyclobenzaprine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
Почему это происходит
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
Что делать
Do not combine; allow at least 14 days after stopping the isocarboxazid before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the isocarboxazid.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Cyclobenzaprine
- Cyclobenzaprine + Linezolid Противопоказано
- Cyclobenzaprine + Phenelzine Противопоказано
- Cyclobenzaprine + Safinamide Противопоказано
- Cyclobenzaprine + Selegiline Противопоказано
- Cyclobenzaprine + Selegiline transdermal Противопоказано
- Cyclobenzaprine + Tranylcypromine Противопоказано
Другие взаимодействия Isocarboxazid
- 5-HTP + Isocarboxazid Противопоказано
- Amitriptyline + Isocarboxazid Противопоказано
- Amobarbital + Isocarboxazid Противопоказано
- Amoxapine + Isocarboxazid Противопоказано
- Apraclonidine + Isocarboxazid Противопоказано
- Atomoxetine + Isocarboxazid Противопоказано
Частые вопросы
Can I take Cyclobenzaprine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the isocarboxazid before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the isocarboxazid.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Linezolid, Phenelzine, Safinamide. The full list is on the Cyclobenzaprine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
