Лекарственные взаимодействия
Cyclobenzaprine + Safinamide
Тяжесть: Противопоказано
Cyclobenzaprine and Safinamide: contraindicated interaction.
Последнее обновление
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Кратко
Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Что означает это взаимодействие простыми словами
Cyclobenzaprine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Safinamide belongs to Central Nervous System.
Почему это происходит
Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition
Что делать
Do not combine; allow at least 14 days after stopping the safinamide before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the safinamide.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Противопоказано
- Cyclobenzaprine + Linezolid Противопоказано
- Cyclobenzaprine + Phenelzine Противопоказано
- Cyclobenzaprine + Selegiline Противопоказано
- Cyclobenzaprine + Selegiline transdermal Противопоказано
- Cyclobenzaprine + Tranylcypromine Противопоказано
Другие взаимодействия Safinamide
- Amitriptyline + Safinamide Противопоказано
- Amoxapine + Safinamide Противопоказано
- Amphetamine polistirex + Safinamide Противопоказано
- Clomipramine + Safinamide Противопоказано
- Desipramine + Safinamide Противопоказано
- Desvenlafaxine + Safinamide Противопоказано
Частые вопросы
Can I take Cyclobenzaprine with Safinamide?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the safinamide.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
