Лекарственные взаимодействия
Desipramine + Safinamide
Тяжесть: Противопоказано
Desipramine and Safinamide: contraindicated interaction.
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Кратко
Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Что означает это взаимодействие простыми словами
Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Почему это происходит
Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition
Что делать
Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Desipramine
- Desipramine + Disopyramide Противопоказано
- Desipramine + Dofetilide Противопоказано
- Desipramine + Ibutilide Противопоказано
- Desipramine + Isocarboxazid Противопоказано
- Desipramine + Methylene blue Противопоказано
- Desipramine + Pentamidine Противопоказано
Другие взаимодействия Safinamide
- Amitriptyline + Safinamide Противопоказано
- Amoxapine + Safinamide Противопоказано
- Amphetamine polistirex + Safinamide Противопоказано
- Clomipramine + Safinamide Противопоказано
- Cyclobenzaprine + Safinamide Противопоказано
- Desvenlafaxine + Safinamide Противопоказано
Частые вопросы
Can I take Desipramine with Safinamide?
MediHelp rates the interaction as contraindicated. Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
