Лекарственные взаимодействия
Domperidone + Polyethylene Glycol 3350
Тяжесть: Умеренное
Domperidone and Polyethylene Glycol 3350: moderate interaction.
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Кратко
There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
Что означает это взаимодействие простыми словами
Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Почему это происходит
Pharmacodynamic and indirect: laxative-induced fluid and electrolyte loss lowers potassium and magnesium, which potentiates the QT-prolonging effect of domperidone. No pharmacokinetic interaction is expected.
Что делать
Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
О чём спросить фармацевта
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Источники
- Domperidone Summary of Product Characteristics - Special warnings and precautions (cardiovascular effects, electrolyte disturbances) — EMA SmPC
- Domperidone: risks of cardiac side effects - restricted indications, new contraindications, and reduced dose and duration of use — MHRA Drug Safety Update
Другие взаимодействия Domperidone
- Azithromycin + Domperidone Противопоказано
- Domperidone + Erythromycin Противопоказано
- Dexlansoprazole + Domperidone Умеренное
- Domperidone + Lansoprazole Умеренное
- Domperidone + Pantoprazole Умеренное
- Domperidone + Rabeprazole Умеренное
Частые вопросы
Can I take Domperidone with Polyethylene Glycol 3350?
MediHelp rates the interaction as moderate. Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
How serious is the interaction between Domperidone and Polyethylene Glycol 3350?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
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