Лекарственные взаимодействия
Ergoloid mesylates + Sumatriptan
Тяжесть: Противопоказано
Ergoloid mesylates and Sumatriptan: contraindicated interaction.
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Кратко
Both drugs can constrict blood vessels, so taking them close together may produce prolonged vasospasm and reduced blood flow to the heart, brain or limbs. Ergoloid mesylates has weaker vasoconstrictor activity than classic ergot alkaloids, but labeling for triptans still advises against combining them with ergot-type drugs.
Что означает это взаимодействие простыми словами
Ergoloid mesylates and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Additive vasoconstriction through 5-HT1B/1D agonism (triptan) and ergot-derived serotonergic and adrenergic receptor effects.
Что делать
Avoid concurrent use and keep at least 24 hours between a triptan and an ergot-type drug. Choose a single agent for the acute indication.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Sumatriptan
- Almotriptan + Sumatriptan Противопоказано
- Dihydroergotamine intranasal + Sumatriptan Противопоказано
- Dihydroergotamine + Sumatriptan Противопоказано
- Eletriptan + Sumatriptan Противопоказано
- Ergotamine + Sumatriptan Противопоказано
- Frovatriptan + Sumatriptan Противопоказано
Частые вопросы
Can I take Ergoloid mesylates with Sumatriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Sumatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can constrict blood vessels, so taking them close together may produce prolonged vasospasm and reduced blood flow to the heart, brain or limbs. Ergoloid mesylates has weaker vasoconstrictor activity than classic ergot alkaloids, but labeling for triptans still advises against combining them with ergot-type drugs.
How serious is the interaction between Ergoloid mesylates and Sumatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep at least 24 hours between a triptan and an ergot-type drug. Choose a single agent for the acute indication.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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