Лекарственные взаимодействия
Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Тяжесть: Противопоказано
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
Последнее обновление
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Кратко
Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
Что означает это взаимодействие простыми словами
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
The mechanism of the ALT elevation is not established; ritonavir also inhibits CYP3A4 and may raise drospirenone exposure.
Что делать
Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Противопоказано
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Противопоказано
- Ethinyl estradiol-drospirenone + Tranexamic acid Противопоказано
- Aminocaproic acid + Ethinyl estradiol-drospirenone Тяжёлое
- Amobarbital + Ethinyl estradiol-drospirenone Тяжёлое
- Anastrozole + Ethinyl estradiol-drospirenone Тяжёлое
Частые вопросы
Can I take Ethinyl estradiol-drospirenone with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
