Лекарственные взаимодействия
Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir
Тяжесть: Противопоказано
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir: contraindicated interaction.
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Кратко
Ethinyl estradiol-containing contraceptives given with this HCV regimen have been associated with significant ALT elevations. The regimen is labeled as contraindicated with ethinyl estradiol products. The interaction is hepatic rather than a CYP3A4 effect of drospirenone.
Что означает это взаимодействие простыми словами
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Mechanism of ALT elevation is not fully established; it is a labeled hepatotoxicity signal with ethinyl estradiol and this regimen.
Что делать
Do not combine; switch to a progestin-only or non-hormonal contraceptive before starting the regimen. Ethinyl estradiol products may be resumed about 2 weeks after completing therapy.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Противопоказано
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Противопоказано
- Ethinyl estradiol-drospirenone + Tranexamic acid Противопоказано
- Aminocaproic acid + Ethinyl estradiol-drospirenone Тяжёлое
- Amobarbital + Ethinyl estradiol-drospirenone Тяжёлое
- Anastrozole + Ethinyl estradiol-drospirenone Тяжёлое
Частые вопросы
Can I take Ethinyl estradiol-drospirenone with Ombitasvir / paritaprevir / ritonavir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ethinyl estradiol-containing contraceptives given with this HCV regimen have been associated with significant ALT elevations. The regimen is labeled as contraindicated with ethinyl estradiol products. The interaction is hepatic rather than a CYP3A4 effect of drospirenone.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a progestin-only or non-hormonal contraceptive before starting the regimen. Ethinyl estradiol products may be resumed about 2 weeks after completing therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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