Лекарственные взаимодействия
Lidocaine + Procainamide
Тяжесть: Тяжёлое
Lidocaine and Procainamide: major interaction.
Последнее обновление
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Кратко
Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
Что означает это взаимодействие простыми словами
Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Почему это происходит
Additive sodium channel blockade slowing cardiac conduction, with overlapping CNS toxicity.
Что делать
Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
О чём спросить фармацевта
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Другие взаимодействия Lidocaine
- Bupivacaine liposome + Lidocaine Тяжёлое
- Disopyramide + Lidocaine Тяжёлое
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Тяжёлое
- Lidocaine + Nirmatrelvir / ritonavir Тяжёлое
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Тяжёлое
- Lidocaine + Pimozide Тяжёлое
Частые вопросы
Can I take Lidocaine with Procainamide?
MediHelp rates the interaction as major. Lidocaine and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are class I antiarrhythmics that depress cardiac conduction, so combined use can cause additive effects such as conduction delay, hypotension and proarrhythmia. Additive CNS toxicity, such as confusion or seizures, has also been described with both agents.
How serious is the interaction between Lidocaine and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only with continuous ECG and blood pressure monitoring, and avoid unless clearly necessary. Reduce doses and watch for QRS widening, hypotension and neurologic symptoms.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
Откройте полный справочник, проверяйте взаимодействия нескольких препаратов и пользуйтесь инструментами дозирования в приложении MediHelp.
