Лекарственные взаимодействия
Measles mumps and rubella vaccine + Methotrexate
Тяжесть: Противопоказано
Measles mumps and rubella vaccine and Methotrexate: contraindicated interaction.
Последнее обновление
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Кратко
Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
Что означает это взаимодействие простыми словами
Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Methotrexate belongs to Oncology.
Почему это происходит
Antimetabolite-induced immunosuppression impairs the immune response to live attenuated virus and permits vaccine virus replication.
Что делать
Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Противопоказано
- Anakinra + Measles mumps and rubella vaccine Противопоказано
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Противопоказано
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Противопоказано
- Azathioprine + Measles mumps and rubella vaccine Противопоказано
- Basiliximab + Measles mumps and rubella vaccine Противопоказано
Другие взаимодействия Methotrexate
- Acitretin + Methotrexate Противопоказано
- Adenovirus types 4 and 7 live + Methotrexate Противопоказано
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Противопоказано
- Ketorolac + Methotrexate Противопоказано
- Measles mumps and rubella vaccine live + Methotrexate Противопоказано
- Measles mumps rubella and varicella vaccine live + Methotrexate Противопоказано
Частые вопросы
Can I take Measles mumps and rubella vaccine with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
How serious is the interaction between Measles mumps and rubella vaccine and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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