Лекарственные взаимодействия
Prednisone + Smallpox vaccine live
Тяжесть: Противопоказано
Prednisone and Smallpox vaccine live: contraindicated interaction.
Последнее обновление
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Кратко
The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
Что означает это взаимодействие простыми словами
Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Почему это происходит
Corticosteroid-induced immunosuppression permits uncontrolled replication of live vaccinia virus and reduces vaccine response.
Что делать
Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
О чём спросить фармацевта
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Другие взаимодействия Prednisone
- Bcg vaccine live + Prednisone Противопоказано
- Measles vaccine + Prednisone Противопоказано
- Mifepristone + Prednisone Противопоказано
- Prednisone + Radium-223 dichloride Противопоказано
- Adenovirus types 4 and 7 live + Prednisone Тяжёлое
- Aldesleukin + Prednisone Тяжёлое
Частые вопросы
Can I take Prednisone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Prednisone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live vaccinia vaccine can cause progressive vaccinia or generalized infection in immunosuppressed patients, and prednisone also weakens the immune response to it. The result can be severe vaccine-related disease and reduced protection.
How serious is the interaction between Prednisone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid replicating vaccinia vaccine in patients on immunosuppressive prednisone doses; use a non-replicating vaccine if one is available and indicated. Defer vaccination until steroids have been stopped for an adequate interval, unless the exposure risk is high.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
Полные монографии, дозировки и проверка взаимодействий в приложении MediHelp
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