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Colchicine + Cyclosporine

شدت: مانع استعمال

Colchicine and Cyclosporine: contraindicated interaction.

آخری تازہ کاری

صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔

اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔

خلاصہ

Cyclosporine inhibits P-glycoprotein and CYP3A4, both of which clear colchicine, so colchicine exposure rises substantially. Fatal colchicine toxicity and myopathy have been reported with this pairing, and cyclosporine itself can cause myotoxicity and nephrotoxicity.

اس تعامل کا آسان لفظوں میں مطلب

Colchicine and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

شواہد کی سطح: High

ایسا کیوں ہوتا ہے

Cyclosporine inhibits P-gp efflux and CYP3A4 metabolism of colchicine, increasing its exposure.

کیا کرنا ہے

Avoid the combination, and it is contraindicated in patients with renal or hepatic impairment. If colchicine is essential, use a substantially reduced dose per labeling and monitor closely for myopathy, cytopenias and diarrhea.

فارماسسٹ سے کیا پوچھیں

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ اراکین کے لیے

پورا صفحہ کھولیں

Colchicine اور Cyclosporine کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

ویب پر 14 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔

اکثر پوچھے جانے والے سوالات

Can I take Colchicine with Cyclosporine?

MediHelp rates the interaction as contraindicated. Colchicine and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits P-glycoprotein and CYP3A4, both of which clear colchicine, so colchicine exposure rises substantially. Fatal colchicine toxicity and myopathy have been reported with this pairing, and cyclosporine itself can cause myotoxicity and nephrotoxicity.

How serious is the interaction between Colchicine and Cyclosporine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and it is contraindicated in patients with renal or hepatic impairment. If colchicine is essential, use a substantially reduced dose per labeling and monitor closely for myopathy, cytopenias and diarrhea.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Ensitrelvir. The full list is on the Colchicine page.

MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر

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