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Colchicine + Nirmatrelvir

شدت: مانع استعمال

Colchicine and Nirmatrelvir: contraindicated interaction.

آخری تازہ کاری

صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔

اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔

خلاصہ

Nirmatrelvir is used with ritonavir, which strongly inhibits CYP3A4 and P-glycoprotein, and can greatly increase colchicine exposure. This risks fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.

اس تعامل کا آسان لفظوں میں مطلب

Colchicine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Colchicine belongs to Genitourinary; Nirmatrelvir belongs to Anti Virals.

شواہد کی سطح: High

ایسا کیوں ہوتا ہے

Inhibition of CYP3A4 and P-glycoprotein by the ritonavir-boosted regimen reduces colchicine clearance.

کیا کرنا ہے

Avoid during the course; withhold colchicine or use an alternative for the duration of treatment as advised by the labeling. In renal or hepatic impairment do not combine.

فارماسسٹ سے کیا پوچھیں

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ اراکین کے لیے

پورا صفحہ کھولیں

Colchicine اور Nirmatrelvir کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

ویب پر 14 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔

اکثر پوچھے جانے والے سوالات

Can I take Colchicine with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Colchicine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is used with ritonavir, which strongly inhibits CYP3A4 and P-glycoprotein, and can greatly increase colchicine exposure. This risks fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.

How serious is the interaction between Colchicine and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during the course; withhold colchicine or use an alternative for the duration of treatment as advised by the labeling. In renal or hepatic impairment do not combine.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.

MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر

MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔

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