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Duloxetine + Linezolid

شدت: مانع استعمال

Duloxetine and Linezolid: contraindicated interaction.

آخری تازہ کاری ماخذ: US FDA label

صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔

اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔

خلاصہ

Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.

اس تعامل کا آسان لفظوں میں مطلب

Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Duloxetine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.

شواہد کی سطح: High

ایسا کیوں ہوتا ہے

Linezolid inhibits MAO and reduces serotonin breakdown, while duloxetine blocks serotonin and norepinephrine reuptake, producing excessive serotonergic stimulation.

کیا کرنا ہے

Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.

فارماسسٹ سے کیا پوچھیں

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ اراکین کے لیے

پورا صفحہ کھولیں

Duloxetine اور Linezolid کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

ویب پر 7 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔

حوالہ جات

اکثر پوچھے جانے والے سوالات

Can I take Duloxetine with Linezolid?

MediHelp rates the interaction as contraindicated. Duloxetine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a weak reversible nonselective MAO inhibitor, and combining it with duloxetine can cause serotonin syndrome. Features include agitation, confusion, tremor, clonus, hyperreflexia, sweating and fever, and the condition can be life threatening. Duloxetine labeling restricts its use with linezolid except in emergencies where benefits outweigh the risk.

How serious is the interaction between Duloxetine and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antibiotic where possible. If linezolid is urgently required, stop duloxetine and monitor for serotonin toxicity for about 2 weeks or until 24 hours after the last linezolid dose, whichever comes first.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.

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