Drug interactions
duloxetine + linezolid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Risk of serotonin syndrome and hypertensive reactions when SNRI is combined with MAO-inhibiting antibiotic.
Mechanism of action
Pharmacodynamic: Linezolid is a reversible nonselective MAO inhibitor → reduced serotonin metabolism; duloxetine increases synaptic serotonin/norepinephrine.
Clinical management
Avoid combination. If linezolid is essential, hold duloxetine prior to initiation, monitor closely for serotonin toxicity during therapy, and resume duloxetine ≥24 h after the last linezolid dose once stable.
Drug reference
References
- Cymbalta (duloxetine) Prescribing Information — FDA Label
- Zyvox (linezolid) Prescribing Information — FDA Label
- Linezolid: Drug Interactions — Lexicomp
Frequently asked questions
Can I take duloxetine with linezolid?
The interaction is rated: Contraindicated. Risk of serotonin syndrome and hypertensive reactions when SNRI is combined with MAO-inhibiting antibiotic.
How serious is the interaction between duloxetine and linezolid?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between duloxetine and linezolid managed?
Avoid combination. If linezolid is essential, hold duloxetine prior to initiation, monitor closely for serotonin toxicity during therapy, and resume duloxetine ≥24 h after the last linezolid dose once stable.
Why do duloxetine and linezolid interact?
Pharmacodynamic: Linezolid is a reversible nonselective MAO inhibitor → reduced serotonin metabolism; duloxetine increases synaptic serotonin/norepinephrine.
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