دوا کے تعاملات
Nitroglycerin + Sildenafil
شدت: مانع استعمال
Nitroglycerin and Sildenafil: contraindicated interaction.
آخری تازہ کاری ماخذ: US FDA label
صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔
اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔
خلاصہ
Sildenafil greatly potentiates the vasodilator effect of nitrates, which can produce profound, prolonged hypotension, syncope, myocardial ischemia or infarction. Patients with coronary disease who use nitrates are the typical population at risk. Labeling of both drugs contraindicates the combination.
اس تعامل کا آسان لفظوں میں مطلب
Nitroglycerin and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
ایسا کیوں ہوتا ہے
Nitroglycerin releases nitric oxide to increase cGMP, while sildenafil inhibits PDE5-mediated cGMP breakdown, causing exaggerated vasodilation.
کیا کرنا ہے
Do not give nitrates to patients who have taken sildenafil within 24 hours. Patients with chest pain who recently took sildenafil need urgent medical assessment and non-nitrate approaches, and nitrates should be avoided for at least 24 hours after the dose.
فارماسسٹ سے کیا پوچھیں
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ اراکین کے لیے
پورا صفحہ کھولیں
Nitroglycerin اور Sildenafil کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
ویب پر 7 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔
حوالہ جات
Nitroglycerin کے دیگر تعاملات
- Avanafil + Nitroglycerin مانع استعمال
- Nitroglycerin + Riociguat مانع استعمال
- Nitroglycerin + Tadalafil مانع استعمال
- Nitroglycerin + Vardenafil مانع استعمال
- Dihydroergotamine intranasal + Nitroglycerin شدید
- Dihydroergotamine + Nitroglycerin شدید
Sildenafil کے دیگر تعاملات
- Amyl nitrite + Sildenafil مانع استعمال
- Atazanavir + Sildenafil مانع استعمال
- Cobicistat + Sildenafil مانع استعمال
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil مانع استعمال
- Glyceryl trinitrate pr + Sildenafil مانع استعمال
- Isosorbide dinitrate + Sildenafil مانع استعمال
اکثر پوچھے جانے والے سوالات
Can I take Nitroglycerin with Sildenafil?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sildenafil greatly potentiates the vasodilator effect of nitrates, which can produce profound, prolonged hypotension, syncope, myocardial ischemia or infarction. Patients with coronary disease who use nitrates are the typical population at risk. Labeling of both drugs contraindicates the combination.
How serious is the interaction between Nitroglycerin and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give nitrates to patients who have taken sildenafil within 24 hours. Patients with chest pain who recently took sildenafil need urgent medical assessment and non-nitrate approaches, and nitrates should be avoided for at least 24 hours after the dose.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Tadalafil. The full list is on the Nitroglycerin page.
MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر
MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔
