Drug interactions
nitroglycerin + sildenafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Profound hypotension/syncope; contraindicated.
Mechanism of action
Excess cGMP via PDE5 inhibition + nitrate.
Clinical management
Do not co-administer within specified washout periods.
Drug reference
References
Frequently asked questions
Can I take nitroglycerin with sildenafil?
The interaction is rated: Contraindicated. Profound hypotension/syncope; contraindicated.
How serious is the interaction between nitroglycerin and sildenafil?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between nitroglycerin and sildenafil managed?
Do not co-administer within specified washout periods.
Why do nitroglycerin and sildenafil interact?
Excess cGMP via PDE5 inhibition + nitrate.
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