دوا کے تعاملات
Riociguat + Sildenafil
شدت: مانع استعمال
Riociguat and Sildenafil: contraindicated interaction.
آخری تازہ کاری ماخذ: US FDA label
صرف صحت کے پیشہ ور افراد کے لیے — محض حوالے کے طور پر۔ یہ صفحہ مختصر خلاصہ ہے، طبی مشورہ نہیں، اور سرکاری لیبل یا طبی فیصلے کا متبادل نہیں۔ تجویز یا فراہمی سے پہلے ہمیشہ تصدیق کریں۔
اس صفحے کا طبی مواد صرف انگریزی میں دستیاب ہے۔
خلاصہ
Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
اس تعامل کا آسان لفظوں میں مطلب
Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
ایسا کیوں ہوتا ہے
Riociguat stimulates soluble guanylate cyclase to raise cGMP, and sildenafil blocks cGMP degradation via PDE5, so the effects on the nitric oxide-cGMP pathway are additive.
کیا کرنا ہے
Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
فارماسسٹ سے کیا پوچھیں
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ اراکین کے لیے
پورا صفحہ کھولیں
Riociguat اور Sildenafil کے لیے مکمل طبی انتظام کی رہنمائی، اضافی نوٹس، شواہد کی تفصیل اور پورے نسخے کا تعامل چیکر کھولنے کے لیے اکاؤنٹ بنائیں اور Pro+ ٹرائل شروع کریں۔
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
ویب پر 14 دن تک Pro+ مفت آزمائیں۔ کارڈ کی ضرورت نہیں۔
حوالہ جات
- Adempas (riociguat) Prescribing Information - Contraindications — FDA Label
- Adempas (riociguat) Summary of Product Characteristics — EMA SmPC
Riociguat کے دیگر تعاملات
- Avanafil + Riociguat مانع استعمال
- Dipyridamole + Riociguat مانع استعمال
- Isosorbide dinitrate + Riociguat مانع استعمال
- Isosorbide mononitrate + Riociguat مانع استعمال
- Nitroglycerin + Riociguat مانع استعمال
- Riociguat + Tadalafil مانع استعمال
Sildenafil کے دیگر تعاملات
- Amyl nitrite + Sildenafil مانع استعمال
- Atazanavir + Sildenafil مانع استعمال
- Cobicistat + Sildenafil مانع استعمال
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil مانع استعمال
- Glyceryl trinitrate pr + Sildenafil مانع استعمال
- Isosorbide dinitrate + Sildenafil مانع استعمال
اکثر پوچھے جانے والے سوالات
Can I take Riociguat with Sildenafil?
MediHelp rates the interaction as contraindicated. Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
How serious is the interaction between Riociguat and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
What other medicines interact with Riociguat?
MediHelp also lists interactions of Riociguat with, for example, Avanafil, Dipyridamole, Isosorbide dinitrate. The full list is on the Riociguat page.
MediHelp ایپ میں مکمل مونوگراف، خوراک اور تعامل چیکر
MediHelp ایپ میں مکمل حوالہ کھولیں، متعدد ادویات کے تعاملات جانچیں اور خوراک کے ٹولز استعمال کریں۔
